Methodical Guidelines

A list of current methodical guidelines on the determination of chemical compounds and hazardous substances in human bio-samples and environmental media, which have been developed by the Center research team over the period 1999-2012.

The methodical guidelines were developed in accordance with the National Standard of the Russian Federation – GOST R 8.563-96 - State System for Ensuring the Uniformity of Measurements. Procedures of Measurements.

1. МУК 4.1.763—99: A gas chromatographic method for the quantitative determination of acetone in bio-samples (urine).
2. МУК 4.1.764—99: A gas chromatographic method for the quantitative determination of saturated (hexane, heptane) and aromatic (benzene, toluene, ethylbenzene, o-, m-, p-xylene) hydrocarbons in bio-samples (urine).
3. МУК 4.1.765—99: A gas chromatographic method for the quantitative determination of aromatic (benzene, toluene, ethylbenzene, o-, m-, p-xylene) hydrocarbons in bio-samples (blood).
4. МУК 4.1.766—99: A gas chromatographic method for the quantitative determination of aromatic amino compounds (aniline, N-methylaniline, о-toluidine, N,N-dimethylaniline, N-ethylaniline, N,N-diethylaniline) in bio-samples (urine).
5. МУК 4.1.767—99: A gas chromatographic method for the quantitative determination of aromatic amino compounds (aniline, N- methylaniline, о- toluidine, N-dimethylaniline, N-ethylaniline, N,N-diethylaniline) in bio-samples (blood).
6. МУК 4.1.768—99: A method for the quantitative determination of exogenous phenol in bio-samples (urine).
7. МУК 4.1.769—99: The quantitative determination of formaldehyde in urine using high-performance liquid chromatography.
8. МУК 4.1.770—99: The quantitative determination of formaldehyde in blood using high-performance liquid chromatography.
9. МУК 4.1.771—99: Gas chromatographic determination of methanol, ethanol, isopropanol, propanol, isobutanol and butanol concentrations in urine.
10. МУК 4.1.772—99: Gas chromatographic determination of methanol, ethanol, isopropanol, propanol, isobutanol and butanol concentrations in blood.
11. МУК 4.1.773—99: The quantitative determination of fluorine ions in urine using an ion-selective electrode.
12. МУК 4.1.774-99: The determination of iron, zinc and nickel concentrations in urine using atomic absorption.
13. МУК 4.1.775-99: The determination of iron, zinc and nickel concentrations in bile using atomic absorption.
14. МУК 4.1.776-99: The determination of iron, zinc, nickel, copper and chromium concentrations in hair using atomic absorption.
15. МУК 4.1.777-99: The determination of zinc, nickel, copper and chromium in blood using atomic absorption.
16. МУК 4.1.778-99: The determination of zinc, nickel, copper and chromium in human breast milk using atomic absorption.
17. МУК 4.1.779-99: The determination of manganese and lead in urine using atomic absorption.
18. МУК 4.1.2103-06: The determination of vanadium mass concentrations in blood samples using electrothermal atomization atomic absorption spectrometry.
19. МУК 4.1.2104-06: The determination of mass concentrations of copper, magnesium and cadmium in urine samples using atomic absorption spectrometry.
20. МУК 4.1.2105-06: The determination of mass concentrations of manganese, lead and magnesium in hair samples using atomic absorption spectrometry.
21. МУК 4.1.2106-06: The determination of mass concentrations of manganese, lead and magnesium in blood samples using atomic absorption spectrometry.
22. МУК 4.1.2107-06: The determination of phenol mass concentrations in bio-samples (urine) using gas chromatography.
23. МУК 4.1.2108-06: The determination of phenol mass concentrations in bio-samples (blood) using gas chromatography.
24. МУК 4.1.2109-06: The determination of 2-chlorophenol mass concentrations in bio-samples (urine) using gas chromatography.
25. МУК 4.1.2110-06: The determination of mass concentrations of formaldehyde, acetaldehyde, propionaldehyde, butyraldehyde and acetone in urine samples using high-performance liquid chromatography.
26. МУК 4.1.2111-06: The determination of mass concentrations of formaldehyde, acetaldehyde, propionaldehyde, butyraldehyde and acetone in blood samples using high-performance liquid chromatography.
27. МУК 4.1.2112-06: The determination of mass concentrations of chloroform, 1,2-dichloroethane, tetrachloromethane and chlorobenzene in bio-samples (blood) using gas chromatography.
28. МУК 4.1.2113-06: The determination of mass concentrations of chloroform, 1,2-dichloroethane and tetrachloromethane in bio-samples (urine) using head space gas chromatography.
29. МУК 4.1.2114-06: The determination of mass concentrations of chloroform, 1,2-dichloroethane, tetrachloromethane and chlorobenzene in bio-samples (urine) using gas chromatography.
30. МУК 4.1.2115-06: The determination of mass concentrations of chloroform, 1,2-dichloroethane and tetrachloromethane in bio-samples (blood) using head space gas chromatography.
31. МУК 4.1.2771-10: The determination of mass concentrations of formaldehyde, acetaldehyde, butyraldehyde and acetone in bile using high-performance liquid chromatography.
32. МУК 4.1.2774-10: The determination of mass concentrations of manganese, lead and nickel in bile using atomic absorption analysis.
33. МУК 4.1.2773-10: The determination of mass concentrations of volatile fatty acids in bio-samples (blood) using gas chromatography.
34. МУК 4.1.2772-10: The determination of phthalic acid mass concentrations in blood samples using high-performance liquid chromatography.
35. МУК 4.1.2956-11: The determination of 1,3-butadiene mass concentrations in ambient air.
36. МУК 4.1.2954-11: The determination of mass concentrations of terephthalic acid dimethyl ester (dimethyl terephthalate) in urine using high-performance liquid chromatography.
37. МУК 4.1.2955-11: The determination of mass concentrations of terephthalic acid dimethyl ester (dimethyl terephthalate) in blood using high-performance liquid chromatography.
38. МУК 4.1.2953-11: The determination of vanadium in ambient air.
39. МУК 4.1.2116-06: The determination of styrene mass concentrations in blood samples using high-performance liquid chromatography.
40. МУК 4.1.3037-12: Measuring copper and zinc mass concentrations in bile using atomic absorption spectrometry.
41. МУК 4.1.3038-12: Measuring acrylonitrile mass concentrations in ambient air using capillary gas chromatography.
42. МУК 4.1.3039-12: Measuring ethylene oxide (oxirane) mass concentrations in ambient air using capillary gas chromatography.
43. МУК 4.1.3040-12: Measuring benzo(a)pyrene mass concentrations in blood using high-performance liquid chromatography.
44. МУК 4.1.3041-12: Measuring benzo(a)pyrene mass concentrations in urine using high-performance liquid chromatography.

1. Methodical Guidelines 2.1.6.792-99 Choosing of the basic indicators for the social hygienic monitoring (ambient air).
2. Manual 2.1.10.1920 – 04 Manual on health risk assessment for the population under the environmental chemicals impact.
3. МР 2.1.10.0033-11 Health risk assessment for the population under the lifeway factors pressure.
4. МР 2.2.2.0021-11 Substantiation of the in-process monitoring programs for the powder metallurgy plants.
5. МР 2.1.10.0059-12 Health risk assessment for the population under the traffic noise impact.
6. МР 2.1.10.0061-12 Health risk assessment for the population under the alternating magnetic field (300 hhertz) in settlements.
7. МР 2.1.10.0057-12 Health risk and harm assessment under climate changes influencing on morbidity and mortality increasing in population of risk groups.
8. МР 2.1.10.0062-12 Quantitative evaluation of the nononcogenic risk assessment under the chemical substances impact using the evolution modeling.
9. МР 2.1.10.0067-12 Health risk assessment for the population under the impact of food microbial contamination. Methodical basis, principles and evaluation criteria.
10. МР 2.1.10.0073-13 Preventive care for respiratory system in children living under the acrogenic pressure of manganese and manganese compounds.
11. МР 1.2.00-74-13 Determination of the maximum permissible concentration for chemical substances (not metabolized) in blood according to the health risk criteria under the miltifactorial exposition.
12. МР 1.2.0077-13 Application of the indexes and criteria for benzol biotransformation abnormality in children organism in concern of hygiene evaluation, sanitary epidemiologic investigation and expertise.
13. МР 4.2.00-75-13 List of gene polymorphism markers responsible for specific mutagenic effect of anthropogenic chemicals.
14. МР 2.4.8.0076-13 Alimentary preventative measures for the disorders of antioxidant, conjugation and elimination functions of children glutathione system associated with the aromatic hydrocarbon impact.
15. МР 5.1.0081-13 Benchmark determination for noninfectious morbidity and its application for supervisory measures planning.
16. МР 2.1.10.0082-13 Methods for medical demographical situation evaluation on population level.
17. МР 5.1.00953-14 Estimation of the in fact and averted by regulatory and supervisory actions economical losses caused by population mortality, morbidity and disablement associated with the adverse impact of the environment.
18. МУ 2.1.10.3165-14 Method of application of the results of medical biological researches for proving hazard to the population health caused by the adverse impact of the chemical factors of the environment.