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10-летие науки и технологии Переезд

Synthesis and Analgesic Activity of N,N′-(Ethane-1,2-diyl)bis(spiroazetidin-2ones) Containing Cyclobutane, Cyclopentane or Cyclohexane Fragments

Авторы: 
Nikiforova E.A., Vasilenko L.A., Makhmudov R.R., Zverev D.P., Dmitriev M.V., Baibarodskikh D.V., Kirillov N.F.
Russian Journal of General Chemistry. – 2025. – Vol. 95, No. 7. – P. 1754-1764. – DOI: 10.1134/S107036322560211X. – EDN: ELDIBG.
Ключевые слова: 
Reformatsky reaction, 1-bromocycloalkylcarboxylate, spiroheterocycle, ethylenediamine, azetidin-2-one, analgesic activity

It was found that the Reformatsky reagents, obtained from methyl-1-bromocyclobutane-, 1-bromocyclopentane-, and 1-bromocyclohexanecarboxylates and zinc, react with diimines, derived from ethylenediamine and aromatic aldehydes, in a 2 : 1 molar ratio to form the corresponding bis(spiroazetidin-2-ones). The structure of the obtained compounds was confirmed by single crystal X-ray diffraction analysis. The in vivo analgesic activity of the synthesized compounds was assessed and shown to have pronounced effects, which exceeded those of the reference drug (sodium metamizole).

Год: 
2025

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