Synthesis and Cytostatic Activity of Substituted Derivatives of Sodium 1-Amino-2-cyano-1,6-dioxo-4-{[3-(ethoxycarbonyl)thiophen-2-yl]amino}hexa-2,4-dien-3-olates

A series of new substituted derivatives of sodium 1-amino-1,6-dioxo-2-cyano-4-{[3-(ethoxycarbonyl)thiophen-2-yl]amino}hexa-2,4-dien-3-olates was synthesized by the furan ring opening reaction of substituted 3-thienylimino-3H-furan-2-ones under the action of amide of cyanoacetic acid in the presence of sodium carbonate as a base. The cytotoxic effect on 4T1 breast cancer cells was studied and the acute toxicity of the obtained compounds was assessed. It was found that the obtained compounds have pronounced anticancer activity and are practically non-toxic drugs (hazard class IV).